Understanding cancer through the genome
Lab Overview
The Imielinski Lab investigates how cancer genomes are organized, altered, and interpreted to reveal the biology of cancer and inform precision oncology. We combine computational genomics, technology development, and software engineering to connect fundamental discoveries with the practical challenges of cancer diagnosis and molecular interpretation.
Our academic research explores the structure and spatial organization of cancer genomes, the effects of complex genomic alterations, and the genomic features that reveal a cancer’s cell and tissue of origin. Our clinical and translational work develops the assays, automated workflows, and interpretation tools needed to bring comprehensive genome analysis into clinical practice.
Across these efforts, we build methods that make complex genomic data easier to analyze, visualize, and understand. Our goal is to uncover how changes in the genome shape cancer and translate that knowledge into useful insights for researchers and clinicians.